From north and south:
Exit the A1 motorway at Fabro, turn left in the direction of Fabro Scalo, after 1 Km turn left on SP 54 in the direction of Chiusi. At Km 2.4 of SP 54 turn right in the direction of Santa Maria, Borgo Santa Maria is on the right 1 km after the turn.
From Perugia:
Take the highway toward Firenze and exit at "Madonna Alta". Take SS 220 in direction Citta' della Pieve, drive through Tavernelle and reach Monteleone d'Orvieto. Then turn right in the direction of Fabro on SS 71. After 6 Km. in the town of Santa Maria turn right after "Il Girasole" restaurant. Drive about 800 m. in "via dei Pini" until you reach Borgo Santa Maria.